Exposure to a Complex Cocktail of Environmental Endocrine-Disrupting Compounds Disturbs the Kisspeptin/GPR54 System in Ovine Hypothalamus and Pituitary Gland
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چکیده
منابع مشابه
Exposure to a Complex Cocktail of Environmental Endocrine-Disrupting Compounds Disturbs the Kisspeptin/GPR54 System in Ovine Hypothalamus and Pituitary Gland
BACKGROUND Ubiquitous environmental chemicals, including endocrine-disrupting chemicals (EDCs), are associated with declining human reproductive health, as well as an increasing incidence of cancers of the reproductive system. Verifying such links requires animal models exposed to "real-life," environmentally relevant concentrations/mixtures of EDC, particularly in utero, when sensitivity to ED...
متن کاملThe pituitary gland and hypothalamus
This chapter explores the hypothalamo-pituitary system and provides a brief description of the principal hormones of the anterior and posterior lobes of the pituitary gland. The actions of the individual hormones are discussed in further detail in the chapters dealing with their target glands: hormonal control of the thyroid, parathyroid and adrenal glands is discussed in Chapter 16, hormonal c...
متن کاملThe Hypothalamus and Pituitary Gland
hypothalamic-hypophyseal complex, the gonads, pancreatic islet cells, adrenal glands, thyroid glands, parathyroid glands, ultimobranchial glands and the endocrine cells of the gut. All these organs release hormones into the bloodstream, which act on target tissues by interacting with receptors on the surface of the cell (peptide hormones) or within the cytoplasm or nucleus of the cell (steroid ...
متن کاملThe Pituitary Gland and Hypothalamus
By the end of this section, you will be able to: • Explain the interrelationships of the anatomy and functions of the hypothalamus and the posterior and anterior lobes of the pituitary gland • Identify the two hormones released from the posterior pituitary, their target cells, and their principal actions • Identify the six hormones produced by the anterior lobe of the pituitary gland, their tar...
متن کاملEndocrine-disrupting compounds and mammary gland development: early exposure and later life consequences.
Breast cancer is the most common non-skin cancer among women in this country. Breast cancer risk is significantly influenced by genetics, but over 70% of the women that are diagnosed have noninherited or sporadic cancer. The risk of breast cancer is thought to be modified by lifestyle and environment. Exposures to certain chemicals and hormone-mimicking or endocrine-disrupting compounds (EDCs) ...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2009
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.0900699